\u00e2\u20ac\u0153Nature is the biggest bioterrorist\u00e2\u20ac\u009d:<\/p>\n
Scientists, viagra<\/a> the Risk of Bioterrorism, pills<\/a> and the Freedom to Publish<\/p>\n William Leiss (22 December 2011)<\/p>\n [Nature is the biggest bioterrorist<\/a>] – PDF<\/p>\n The quoted sentence in the title is attributed to R. A. M. Fouchier, ailment<\/a> a scientist at Erasmus Medical Center in Rotterdam and the University of Wisconsin, in an interview with The New York Times<\/em>.[1]<\/a>\u00c2\u00a0 He is the lead researcher for the team that, working in a highly secure laboratory in the Netherlands, genetically engineered the \u00e2\u20ac\u0153highly pathogenic\u00e2\u20ac\u009d avian influenza A(H5N1) virus so as to make it easily transmissible in mammals.\u00c2\u00a0 H5N1 is an extraordinarily lethal group or clade of viruses which has killed about 60% of the 600 or so humans that have been infected by it since 2003 (the virus was first identified in 1997).\u00c2\u00a0 A pertinent comparison is with the 1918 pandemic, which killed only about 1% of those infected.\u00c2\u00a0 The H5N1 viruses are easily transmissible among birds and are sometimes transmitted from birds to humans, but so far there is no evidence for direct human-to-human transmission.<\/p>\n Scientists have been studying its genome in order to understand why human-to-human transmission has been inhibited to date \u00e2\u20ac\u201c knowing that, should this inhibition be overcome, at a time when no vaccine was available, the human death toll around the world could be enormous.\u00c2\u00a0 Scientists have also been trying to manipulate its genetic structure so as to identify exactly what gene changes would allow it to overcome this inhibition; working with ferrets in the laboratory, they now think they know what kinds of gene changes would enable the virus to move freely among members of a mammalian species.\u00c2\u00a0 In the press release from Erasmus Medical Center Professor Fouchier explains why this work was done:\u00c2\u00a0 \u00e2\u20ac\u0153We now know what mutations to watch for in the case of an outbreak and we can then stop the outbreak before it is too late.\u00c2\u00a0 Furthermore, the finding will help in the timely development of vaccinations and medication.\u00e2\u20ac\u009d<\/p>\n Now comes the tricky part.\u00c2\u00a0 The researchers want to publish their work in full, in the journals Science<\/em> and Nature<\/em>, arguing that other researchers working in this same area need to know the details in order to evaluate the results properly.\u00c2\u00a0 But the U. S. National Science Advisory Board for Biosecurity has asked the two journals not to publish major sections of the papers, specifically the \u00e2\u20ac\u0153experimental details and mutation data that would enable replication of the experiments\u00e2\u20ac\u009d \u00e2\u20ac\u201c lest terrorists seek to weaponize the engineered pathogen to deliberately produce a global pandemic.<\/p>\n Professor Fouchier and others prefer to treat the issue as a matter of practicalities:\u00c2\u00a0 (1) terrorist groups cannot easily duplicate the expertise, lab equipment, and development time needed to engineer this virus, even with the blueprint in hand; (2) even if the experimental details are restricted to recognized researchers, the results will eventually be circulated more widely; (3) there are other, available candidate materials for producing biological weapons for terrorist purposes that are far easier to work with.<\/p>\n One problem in resolving this issue is that Professor Fouchier has muddied the waters considerably with his comment about nature being the \u00e2\u20ac\u0153biggest bioterrorist.\u00e2\u20ac\u009d\u00c2\u00a0 Another scientist, Professor John Oxford, London School of Medicine, further clouded the matter with these remarks:\u00c2\u00a0 \u00e2\u20ac\u0153The biggest risk with bird flu is from the virus itself.\u00c2\u00a0 We should forget about bio terrorism and concentrate on Mother Nature.\u00e2\u20ac\u009d[2]<\/a>\u00c2\u00a0 They should both be forced to wear dunce caps and sit in the corner for a while.\u00c2\u00a0 As they should know, by the word \u00e2\u20ac\u0153terrorism\u00e2\u20ac\u009d we refer to deliberate acts of human malevolence and injustice causing great harms in the name of political objectives.\u00c2\u00a0 Its commonest and age-old form is state-sponsored terrorism, such as that being suffered now by the citizens of Syria and dozens of other countries around the world; non-state actors also employ it, on a much less widespread scale, and sometimes in pursuit of legitimate struggles of political resistance against tyrannical regimes.<\/p>\n But Mother Nature is not a terrorist.\u00c2\u00a0 In using this provocative language some scientists are trying to sidestep the very difficult issues in responsible decision making that have been raised by the proposal to publish this research in its entirety.\u00c2\u00a0 These difficulties can be seen if we array the decision problem in the form of offsetting risk scenarios:<\/p>\n \u00c2\u00a0<\/em><\/p>\n Versus<\/em><\/p>\n \u00c2\u00a0<\/em><\/p>\n Framing the choices we face as a set of contrasting risk scenarios is a way of using a systematic and disciplined approach to identify the trade-offs and assumptions that are otherwise hidden in the narrative problem-formulation.\u00c2\u00a0 It also acts as a requirement for participants in the debate to specify what types of evidence could be assembled in support of attempts to answer these specific questions.<\/p>\n It would be possible, were sufficient time and resources to be made available, to undertake a formal set of risk assessments to address these four propositions; or we could just decide to rely on educated guesswork, for example, through an established procedure known as \u00e2\u20ac\u0153expert elicitation\u00e2\u20ac\u009d (http:\/\/en.wikipedia.org\/wiki\/Expert_elicitation<\/a>).\u00c2\u00a0 This is unlikely to happen:\u00c2\u00a0 Some behind-the-scenes jockeying between the scientific journals, the research community, and the U.S. biosecurity committee will produce a resolution of this particular issue that the rest of us will read about later.<\/p>\n However, if either kind of systematic decision analysis were to be carried out and then published, all of us could perhaps learn a bit more about how to make sensible decisions of this type, which might be helpful when the next problem of this type rolls around.\u00c2\u00a0 Because there is a virtual certainty that there will be more problems of this type.\u00c2\u00a0 This is a simple function of the increasing power of scientific investigation itself, especially in highly sensitive areas like genetic manipulation and some others, such as synthetic biology and the detailed understanding and potential manipulation of brain functions.<\/p>\n [1]<\/a> Denis Grady and William J. Broad, \u00e2\u20ac\u0153Seeing terror risk, U.S. asks journals to cut flu study facts\u00e2\u20ac\u009d (http:\/\/tinyurl.com\/89w7cfl<\/a>) and Doreen Carvajal, \u00e2\u20ac\u0153Security in flu study was paramount, scientist says\u00e2\u20ac\u009d (http:\/\/tinyurl.com\/76kn2om<\/a>), The New York Times, <\/em>21 December 2011; Fergus Walsh, \u00e2\u20ac\u0153When should science be censored?\u00e2\u20ac\u009d (20.12.11)\u00c2\u00a0 http:\/\/www.bbc.co.uk\/news\/health-16275946<\/a>.\u00c2\u00a0 \u00c2\u00a0For a very thorough summary of background information see the Wikipedia article at:\u00c2\u00a0 http:\/\/en.wikipedia.org\/wiki\/Influenza_A_virus_subtype_H5N1<\/a>.<\/p>\n<\/div>\n [2]<\/a> See further Richard Ingham, \u00e2\u20ac\u0153Scientists fight back in \u00e2\u20ac\u02dcmutant flu\u00e2\u20ac\u2122 research,\u00e2\u20ac\u009d The Globe and Mail<\/em>, 22 December 2011, A14: \u00c2\u00a0http:\/\/tinyurl.com\/77tm52w<\/a>.<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":" \u00e2\u20ac\u0153Nature is the biggest bioterrorist\u00e2\u20ac\u009d: Scientists, viagra the Risk of Bioterrorism, pills and the Freedom to Publish William Leiss (22 December 2011) [Nature is the biggest bioterrorist] – PDF The quoted sentence in the title is attributed to R. 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